t-Boc-Aminooxy-PEG1-amine is a PEG linker with a Boc-protected aminooxy group and an amine group. The PEG spacer improves solubility in water. The aminooxy group, when deprotected under mild acid, forms stable oxime bonds with aldehydes or ketones. The amine group reacts with carboxylic acids, NHS esters, and carbonyl compounds, offering versatility.
Key Features
- Functional Groups: Includes a Boc-protected aminooxy group and an amine group for dual reactivity.
- Water Solubility: The PEG spacer ensures good solubility in aqueous solutions.
- Reactivity: The deprotected aminooxy group forms oxime linkages with aldehydes or ketones, while the amine group reacts with various chemical groups like carboxylic acids and esters.
Applications
- Bioconjugation: Enables the attachment of biomolecules through oxime ligation.
- Drug Development: Functions as a linker in creating antibody-drug conjugates (ADCs).
- Material Science: Ideal for modifying surfaces with PEGylated compounds to improve biocompatibility.
Specifications
- Molecular Formula: C9H20N2O4
- Molecular Weight: 220.27 g/mol
- Purity: ≥95%
- Storage: Store at -20°C
t-Boc-Aminooxy-PEG1-amine is a versatile tool for applications in bioconjugation, drug development, and material science.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
