TCO-PEG5-TCO
This product is a homobifunctional PEG linker with trans-cyclooctene (TCO) groups at both ends, connected by a PEG5 spacer. The TCO moieties enable ultra-fast, copper-free click chemistry via strain-promoted inverse electron-demand Diels–Alder cycloaddition (SPIEDAC) with tetrazines. The PEG5 spacer improves solubility, reduces steric hindrance, and provides optimal distance between reactive groups, ensuring high-efficiency conjugation in both aqueous and organic environments.
Key Features and Benefits:
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Rapid Bioorthogonal Reactivity: TCO groups react with tetrazines at exceptional speeds without metal catalysts.
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PEG5 Spacer: Enhances hydrophilicity, flexibility, and accessibility of reactive sites.
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High Purity: Delivers reproducible performance in sensitive bioconjugation workflows.
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Copper-Free Chemistry: Safe for live-cell and in vivo labeling.
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Versatile: Compatible with diverse applications in chemical biology and diagnostics.
Applications:
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Bioorthogonal Labeling: Conjugate probes, drugs, or biomolecules to tetrazine-modified targets.
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In Vivo Imaging: Enable pretargeted imaging with rapid, selective labeling.
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Bioconjugation: Assemble multifunctional molecules for therapeutics and research tools.
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Surface and Polymer Modification: Introduce TCO handles for further functionalization.
Storage and Handling:
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Storage: Store at –20 °C, away from light and moisture.
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Handling: Use anhydrous solvents (e.g., DMSO, DMF) and protect from prolonged light exposure to preserve TCO reactivity.
TCO-PEG5-TCO offers fast, selective, and catalyst-free click chemistry specifically for advanced applications in molecular imaging, chemical biology, and targeted therapeutics.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
