Bis-sulfone-PEG24-m
Bis-sulfone-PEG24-m is a high-purity PEG24 crosslinker with a bis-sulfone group for selective thiol conjugation. The long PEG spacer improves solubility, reduces steric hindrance, and provides flexibility, making it especially ideal for cysteine-specific protein modification, ADC development, and surface functionalization.
Key Features and Benefits:
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Bis-sulfone Reactive Group: Selective for thiol groups, enabling controlled cysteine conjugation.
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Long PEG24 Spacer: Improves solubility, flexibility, and accessibility of functional groups.
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High Purity: Reliable for use in sensitive and reproducible biochemical workflows.
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Stable Linkage: Produces robust covalent bonds with thiols for long-term stability.
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Versatile Use: Compatible with both aqueous and organic systems.
Applications:
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Antibody-Drug Conjugates (ADCs): Site-specific conjugation of cytotoxic payloads to antibodies.
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Protein Bioconjugation: Attach peptides, proteins, or biomolecules through cysteine residues.
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Drug Delivery: Spacer-linker for targeted delivery and improved pharmacokinetics.
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Surface Modification: Functionalize nanoparticles, hydrogels, or biomaterials with thiol-reactive handles.
Storage and Handling:
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Storage: Store at –20 °C, protected from light and moisture.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to maintain bis-sulfone stability.
This product combines long-chain PEG spacing with thiol-selective bis-sulfone chemistry, making it an essential crosslinker for advanced protein conjugation and targeted therapeutic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
