Bis-PEG8-NHS ester is a bifunctional, hydrophilic polyethylene glycol (PEG) linker with an 8-unit PEG chain and N-hydroxysuccinimide (NHS) ester groups on both ends. The NHS esters enable efficient conjugation to primary amines, forming stable amide bonds, while the PEG spacer enhances solubility, biocompatibility, and reduces immunogenicity of the resulting conjugates.
In pharmaceutical research and development, Bis-PEG8-NHS ester is employed to construct bioconjugates, such as antibody-drug conjugates (ADCs) and PEGylated proteins. These conjugates improve drug delivery, pharmacokinetics, and therapeutic efficacy. Additionally, Bis-PEG8-NHS ester is utilized in the development of novel targeted therapies, diagnostics, and imaging agents.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
