Bis-PEG5-NHS ester acts as a highly effective bifunctional polyethylene glycol (PEG) linker. It enables fast and stable amine coupling. More importantly, its two reactive N-hydroxysuccinimide (NHS) ester groups allow scientists to crosslink biomolecules like proteins, peptides, and antibodies with precision. Furthermore, the PEG5 spacer boosts solubility in both water and organic solutions. It also reduces steric hindrance and improves biocompatibility. Because of these outstanding properties, Bis-PEG5-NHS ester plays a key role in bioconjugation, drug delivery, and biomaterial engineering.
Key Features
- Bifunctional NHS Ester Groups – Allow quick, efficient, and stable conjugation with primary amines.
- PEG5 Spacer for Better Solubility – Significantly improves solubility while also minimizing steric hindrance for optimal conjugation.
- High Biocompatibility – Reduces immunogenicity and enhances compatibility with biological systems.
- Versatile Reactivity – Supports protein modification, surface functionalization, and hydrogel crosslinking.
- Stable and Reliable Coupling – Provides strong and reproducible results in bioconjugation applications.
Applications
- Protein and Peptide Conjugation – Effortlessly attaches biomolecules to surfaces, carriers, or macromolecules.
- Targeted Drug Delivery – Increases drug stability, bioavailability, and circulation time.
- Nanoparticle and Surface Functionalization – Enhances bioactivity by modifying nanoparticles and polymer surfaces.
- Crosslinking for Biomaterials – Strengthens hydrogel and scaffold structures, which support regenerative medicine applications.
- Diagnostic Assay Development – Improves sensitivity and reliability by enabling efficient antibody labeling.
Conclusion
In summary, Bis-PEG5-NHS ester serves as a powerful and versatile PEG linker. It ensures stable, efficient, and reliable conjugation for many biological and material science applications. With its bifunctional NHS ester groups and advanced PEG5 spacer, it enhances solubility, boosts reactivity, and improves biocompatibility. Because of these benefits, researchers and developers across various fields can confidently rely on this essential reagent for bioconjugation, targeted drug delivery, and biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
