Bis-PEG3-PFP ester
This product is a homobifunctional PEG linker containing two pentafluorophenyl (PFP) ester groups connected by a PEG3 spacer. The PFP esters react efficiently with primary amines to form stable amide bonds, offering greater hydrolytic stability than NHS esters. The PEG3 spacer improves solubility, flexibility, and spacing, making this reagent especially useful for protein crosslinking, PEGylation, and multifunctional conjugation.
Key Features and Benefits
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Dual PFP Ester Groups: Couples efficiently with amines to form stable amides.
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PEG3 Spacer: Provides solubility and moderate chain flexibility.
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Homobifunctional Design: Crosslinks or dimerizes amine-bearing biomolecules.
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Improved Stability: PFP esters resist hydrolysis better than NHS esters.
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High Purity: Manufactured to ≥95% purity for reproducibility.
Applications
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Protein Crosslinking: Links amine-containing proteins, peptides, and antibodies.
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Bioconjugation: Couples biomolecules or nanomaterials via amide chemistry.
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PEGylation: Introduces PEG units to enhance solubility and stability.
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Probe Development: Builds multifunctional probes and diagnostic tools.
Storage and Handling
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use under anhydrous conditions; prepare fresh solutions before use.
This product combines dual amine-reactive groups with a hydrophilic PEG3 backbone, specifically providing an efficient crosslinker for bioconjugation and PEGylation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
