Bis-PEG2-t-butyl ester CAS:1611468-28-0 is a symmetrical, bifunctional PEGylation reagent featuring two t-butyl ester-protected carboxylic acid groups, separated by a PEG2 (polyethylene glycol diol) linker. Its hydrophilic PEG2 spacer imparts water solubility and biocompatibility to the conjugated biomolecules, while the t-butyl ester groups provide a stable, easily cleavable moiety for subsequent deprotection.
Introduction to the Application:
In pharmaceutical research and development, Bis-PEG2-t-butyl ester plays a crucial role in the PEGylation of biomolecules, such as proteins and peptides. This process enhances their pharmacokinetic properties, including increased solubility, stability, and circulation half-life, while reducing immunogenicity. These improvements facilitate the development of more efficacious and safe therapeutics with optimized drug delivery profiles.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
