Bis-PEG2-PFP ester
This product is a homobifunctional PEG linker terminated with two pentafluorophenyl (PFP) ester groups on a short PEG2 chain. The PFP esters react efficiently with primary amines to form stable amide bonds, offering improved hydrolytic stability compared to NHS esters. The PEG2 spacer enhances solubility and flexibility while keeping the structure compact, making this reagent especially useful for protein crosslinking, PEGylation, and multifunctional conjugation.
Key Features and Benefits
-
Dual PFP Ester Groups: Reacts selectively with primary amines for stable amide formation.
-
PEG2 Spacer: Provides hydrophilicity and minimal steric hindrance.
-
Homobifunctional Design: Enables crosslinking or dimerization of amine-bearing biomolecules.
-
Improved Stability: PFP esters resist hydrolysis better than NHS esters.
-
High Purity: Produced to ≥95% purity for reproducibility.
Applications
-
Protein Crosslinking: Links amine-containing proteins and peptides.
-
Bioconjugation: Couples biomolecules or nanoparticles via amide chemistry.
-
PEGylation: Introduces short PEG chains to enhance solubility and stability.
-
Probe Development: Builds multifunctional constructs for imaging and diagnostics.
Storage and Handling
-
Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
-
Handling: Use under anhydrous conditions; prepare fresh solutions to avoid hydrolysis.
This product combines high-efficiency amine reactivity with compact PEG spacing, specifically offering a reliable crosslinker for bioconjugation and PEGylation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
