Biotin-PEG3-Hydrazide
This product is a heterobifunctional PEG3 linker with a biotin moiety and a terminal hydrazide group. The PEG3 spacer provides solubility and flexibility, while the biotin ensures high-affinity binding to avidin/streptavidin systems and the hydrazide enables coupling with aldehydes and ketones for targeted conjugation.
Key Features and Benefits:
-
Biotin Group: Strong binding to avidin and streptavidin proteins for affinity-based applications.
-
Hydrazide Group: Reacts with aldehydes and ketones to form stable hydrazone linkages.
-
PEG3 Spacer: Provides compact hydrophilicity and reduced steric hindrance.
-
High Purity: Ensures reproducibility in bioconjugation workflows.
-
Dual Functionality: Combines affinity labeling with chemoselective conjugation.
Applications:
-
Bioconjugation: Enables biotinylation and aldehyde/ketone coupling of biomolecules.
-
Affinity Labeling: Facilitates capture, detection, and purification with biotin tags.
-
Drug Delivery: Improves solubility and enables biotin-mediated targeting.
-
Surface Functionalization: Functionalizes nanoparticles, hydrogels, and polymers.
Storage and Handling:
-
Storage: Store at –20 °C, protected from moisture and light.
-
Handling: Use anhydrous solvents (e.g., DMF, DMSO) to maintain hydrazide stability.
This product offers dual reactivity with biotin targeting and hydrazide chemistry in a short PEG spacer, making it an especially powerful tool for conjugation and biomolecular labeling.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
