Benzyl-PEG2-Azide
Benzyl-PEG2-azide is a high-purity PEG linker with a benzyl group for hydrophobic interactions and an azide for CuAAC or SPAAC click chemistry. The PEG2 spacer specifically improves solubility, flexibility, and reduces steric hindrance for efficient, orthogonal bioconjugation in aqueous and organic systems.
Key Features and Benefits
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Azide Group – Supports CuAAC and SPAAC click chemistry for rapid, chemoselective conjugation.
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Benzyl Group – Provides hydrophobic interaction capability for specific molecular recognition or membrane association.
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PEG2 Spacer – Improves solubility and flexibility while reducing steric hindrance.
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Orthogonal Reactivity – Allows site-specific modifications without undesired side reactions.
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High Purity – Supplied at >95% purity for consistent and reproducible results.
Applications
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Click chemistry conjugation in chemical biology and materials science
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Hydrophobic tagging of biomolecules or nanoparticles
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Multifunctional probe and imaging agent synthesis
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PEGylation strategies to improve stability and bioavailability
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid prolonged exposure to moisture to preserve reactivity
This product combines hydrophobic benzyl functionality with azide click chemistry, linked by PEG2 for enhanced solubility and flexibility, making it especially ideal for orthogonal bioconjugation and targeted delivery applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.