Benzaldehyde-PEG4-azide
Benzaldehyde-PEG4-azide is a high-purity heterobifunctional PEG linker with a benzaldehyde group for oxime or hydrazone ligation and an azide for bioorthogonal click chemistry (CuAAC or SPAAC). The PEG4 spacer especially enhances solubility, flexibility, and accessibility of reactive groups, enabling efficient bioconjugation in aqueous and organic systems for drug delivery, diagnostics, and advanced materials.
Key Features and Benefits
-
Benzaldehyde Group: Reacts selectively with aminooxy or hydrazide groups to form oxime or hydrazone bonds.
-
Azide Group: Enables copper-catalyzed or strain-promoted click chemistry with alkynes.
-
PEG4 Spacer: Improves solubility and reduces steric hindrance for efficient coupling.
-
Heterobifunctional Design: Supports orthogonal and sequential conjugation strategies.
-
High Purity: Supplied at >95% purity for reproducible, high-yield performance.
Applications
-
Stepwise Bioconjugation: Sequentially couple aldehyde and azide chemistries for multifunctional conjugates.
-
Protein and Peptide Modification: Introduce bioorthogonal handles for labeling and drug conjugation.
-
Nanoparticle Functionalization: Add aldehyde and azide groups to surfaces for targeted delivery.
-
Drug Delivery Systems: Design cleavable or stable linkers for controlled payload release.
-
Diagnostic Probe Development: Create multifunctional imaging and biosensing probes.
Storage and Handling
-
Storage: Store at –20 °C, dry, and protected from light.
-
Handling: Use anhydrous solvents such as DMF or DMSO; avoid moisture to preserve aldehyde reactivity.
Benzaldehyde-PEG4-azide combines aldehyde-based ligation with click chemistry reactivity in a hydrophilic PEG4 framework, enabling orthogonal, high-efficiency linker strategies specifically for targeted therapeutics, diagnostics, and advanced materials.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
