BCN-SS-NHS is a cleavable linker with a BCN (bicyclo[6.1.0]nonyne) group and an NHS (N-hydroxysuccinimide) ester, connected by a disulfide bond. The BCN group enables copper-free click chemistry with azides, while the NHS ester reacts with primary amines to form stable amide bonds. The disulfide bond allows for controlled payload release under reducing conditions.
Key Features:
- Reactive Groups: BCN for click chemistry and NHS ester for amine conjugation.
- Cleavable Bond: Disulfide linkage breaks under reducing conditions for controlled release.
- Molecular Weight: 454.56 g/mol
BCN-SS-NHS Applications:
- Antibody-Drug Conjugates (ADCs): Links drugs to antibodies for targeted cancer therapy.
- Bioconjugation: Attaches biomolecules via click chemistry and amine coupling.
- Protein Labeling: Labels proteins with fluorescent dyes or probes.
- Surface Functionalization: Functionalizes surfaces for biosensors and diagnostic tools.
This versatile linker supports targeted drug delivery, precise bioconjugation, and advanced molecular assembly.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
