BCN-PEG4-HyNic (CAS: 1507370-54-8) is a bifunctional linker designed for bioconjugation and ADC development. It has two reactive groups: BCN for copper-free click chemistry with azides and HyNic for forming hydrazone bonds with carbonyl-containing molecules. The PEG4 spacer improves solubility and flexibility during conjugation.
Key Features:
- Dual Reactivity: The BCN group supports copper-free click chemistry, while the HyNic group forms stable bonds with aldehydes and ketones.
- Enhanced Solubility: The PEG4 spacer increases water solubility and reduces steric hindrance for better molecular interactions.
BCN-PEG4-HyNic Applications:
- ADC Development: Links antibodies to cytotoxic drugs for targeted cancer treatment.
- Bioconjugation: Attaches biomolecules like peptides, proteins, and polymers for research or therapeutic purposes.
How to Use:
- Storage: Keep at -20°C, away from light and moisture, to maintain stability.
- Solubility: Easily dissolves in organic solvents like DMSO for various conjugation protocols.
BCN-PEG4-HyNic is a versatile and efficient linker for creating bioconjugates in therapeutic, diagnostic, and research applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
