Azido-PEG6-t-butyl ester
This product is a high-purity heterobifunctional PEG reagent with an azide group and a tert-butyl ester, specifically connected via a PEG6 spacer for solubility and flexibility.
Key Features and Benefits
-
Azide Group – Enables copper-catalyzed azide–alkyne cycloaddition (CuAAC) or strain-promoted click chemistry.
-
t-Butyl Ester Group – Acid-labile protecting group that can be selectively removed to yield a reactive carboxylic acid.
-
PEG6 Spacer – Provides hydrophilicity, reduces steric hindrance, and enhances linker flexibility.
-
High Purity – Suitable for controlled conjugation and intermediate synthesis in bioconjugation and drug delivery.
Applications
-
Click chemistry with alkynes for stable triazole linkage formation
-
Generation of carboxyl-functional PEG linkers after t-butyl deprotection
-
Development of PEGylated probes, polymers, or biomaterials
-
Use in drug delivery systems, diagnostics, and surface modification
Storage & Handling
-
Storage: Store at –20 °C, dry, and protected from light.
-
Handling: Dissolve in anhydrous solvents (e.g., DMF, DMSO). Avoid repeated freeze–thaw cycles.
This product provides both an azide for click chemistry and a protected ester group for later conversion to carboxylic acid, with a PEG6 spacer specifically ensuring solubility and flexibility for advanced conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
