Azido-PEG6-CH2CO2-tBu
Azido-PEG6-CH2CO2-tBu is a high-purity PEG linker with an azide for click chemistry and a t-butyl ester–protected acid for orthogonal conjugation. The PEG6 spacer enhances solubility and flexibility, ensuring efficient bioconjugation in aqueous and organic systems for drug delivery, diagnostics, and advanced materials.
Key Features and Benefits
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Azide Functional Group: Enables copper-catalyzed or strain-promoted click chemistry with alkynes.
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t-Butyl Ester Protection: Acid-labile, allowing selective deprotection for sequential coupling.
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PEG6 Spacer: Improves solubility, flexibility, and accessibility of reactive groups.
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Heterobifunctional Design: Supports orthogonal conjugation workflows.
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High Purity: Supplied at >95% purity for reproducible, high-yield performance.
Applications
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Stepwise Bioconjugation: Sequentially attach azide and carboxylic acid partners.
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Protein and Peptide Modification: Introduce azide handles while reserving a protected acid for later use.
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Nanoparticle and Surface Functionalization: Add bioorthogonal handles for targeted delivery.
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Drug Delivery Systems: Build linkers for precise payload attachment and release.
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Diagnostic Probe Development: Create multifunctional imaging and sensing probes.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture to preserve reactive groups.
Azido-PEG6-CH2CO2-tBu combines azide click reactivity with acid-protected functionality in a hydrophilic PEG6 spacer, offering a longer, more flexible linker specifically for multifunctional bioconjugates, precision linkers, and targeted delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
