Azido-PEG5-t-butyl ester
Azido-PEG5-t-butyl ester is a high-purity monofunctional PEG derivative featuring an azide group for click chemistry at one end and a t-butyl ester-protected carboxylic acid at the other. The PEG5 spacer specifically improves solubility, flexibility, and biocompatibility, enabling efficient coupling in aqueous and organic systems.
Key Features
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Reactive azide group for copper-catalyzed or strain-promoted azide–alkyne cycloaddition (CuAAC or SPAAC)
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t-Butyl ester protection for controlled carboxylic acid release under mild acidic conditions
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PEG5 spacer enhances hydrophilicity, reduces steric hindrance, and increases molecular flexibility
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High chemical stability and purity
Applications
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Click chemistry-based bioconjugation
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Stepwise synthesis of multifunctional PEG derivatives
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Protein, peptide, and small molecule modification
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Nanoparticle and surface functionalization
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Drug delivery and biomaterial engineering
Storage and Handling
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Store at –20 °C, protected from light and moisture
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Bring to room temperature before opening
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Avoid repeated freeze–thaw cycles
This product contains an azide for click chemistry and a t-butyl ester-protected carboxylic acid, with a PEG5 spacer specifically for enhanced solubility and reduced steric hindrance.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
