Azido-PEG5-succinimidyl carbonate
This product is a high-purity, heterobifunctional PEG reagent featuring an azide group for copper-catalyzed azide–alkyne cycloaddition (CuAAC) or strain-promoted click chemistry, and an NHS carbonate ester for efficient coupling to primary amines. The PEG5 spacer specifically enhances water solubility, provides molecular flexibility, and minimizes steric hindrance, ensuring high-yield conjugation in both aqueous and organic environments. This versatile design is ideal for applications in drug delivery, biomaterials, and diagnostics.
Key Features and Benefits:
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Azide Functional Group: Compatible with CuAAC and strain-promoted click chemistry (SPAAC) for rapid, selective conjugation with alkyne-containing molecules.
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NHS Carbonate Ester: Reacts efficiently with primary amines on proteins, peptides, or other biomolecules to form stable carbamate linkages.
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PEG5 Spacer: Improves aqueous solubility, reduces steric hindrance, and increases accessibility of reactive sites.
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Heterobifunctional Design: Enables sequential or orthogonal conjugation strategies for multifunctional constructs.
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High Purity: Supplied at >95% purity for consistent, reproducible performance in research and development.
Applications:
- Click Chemistry Bioconjugation: Attach biomolecules using azide–alkyne chemistry with high specificity.
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Protein and Peptide Labeling: Modify amine-containing biomolecules with orthogonal azide handles for downstream click reactions.
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Nanoparticle and Surface Modification: Introduce bioorthogonal azide groups to surfaces for targeted delivery or sensing.
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Drug Delivery Systems: Build multifunctional linkers for controlled drug attachment and release.
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Diagnostic Probe Development: Prepare dual-functional imaging or sensing agents.
Storage and Handling:
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture to preserve NHS reactivity.
Azido-PEG5-succinimidyl carbonate offers orthogonal click and amine-reactive chemistries with enhanced solubility, making it an especially versatile tool for multifunctional bioconjugates, targeted drug delivery linkers, and precision materials.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
