Azido-PEG5-CH2CO2-NHS
This product is a heterobifunctional PEG5 linker with a terminal azide for click chemistry and an N-hydroxysuccinimide (NHS) ester for amine coupling. The PEG5 spacer provides hydrophilicity and flexibility, while the azide–NHS combination enables efficient orthogonal bioconjugation strategies.
Key Features and Benefits:
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Azide Group: Supports CuAAC and SPAAC click chemistry with alkyne partners.
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NHS Ester: Couples efficiently with primary amines to form stable amide bonds.
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PEG5 Spacer: Provides solubility, flexibility, and reduced steric hindrance.
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High Purity: Ensures reproducibility in sensitive conjugation workflows.
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Orthogonal Reactivity: Combines click-ready and amine-reactive handles in one linker.
Applications:
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Bioconjugation: Dual-functional linker for proteins, peptides, and biomolecules.
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Click Chemistry: Enables selective labeling via azide–alkyne ligation.
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Drug Delivery: Facilitates linker–payload design with PEGylated solubility.
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Surface Functionalization: Functionalizes nanoparticles, polymers, and hydrogels.
Storage and Handling:
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Storage: Store at –20 °C in a dry, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve NHS and azide stability.
This product combines azide-based click chemistry with NHS ester amine reactivity in a compact PEG spacer, making it an especially versatile reagent for dual bioconjugation and drug delivery workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
