Azido-PEG4-t-butyl ester
This product is a high-purity PEG linker with an azide group for click chemistry and a tert-butyl ester for selective deprotection, specifically connected by a PEG4 spacer for solubility and flexibility.
Key Features and Benefits
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Azide Group – Enables efficient copper-catalyzed or strain-promoted azide–alkyne cycloaddition (CuAAC or SPAAC).
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t-Butyl Ester Group – Provides a protected carboxyl group for controlled deprotection and subsequent conjugation.
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PEG4 Spacer – Improves solubility, reduces steric hindrance, and enhances accessibility in conjugates.
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High Purity – Suitable for bioconjugation, linker synthesis, and probe development.
Applications
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Click chemistry conjugation with alkynes (CuAAC or SPAAC)
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Controlled carboxyl introduction for bioconjugation workflows
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Synthesis of PEG-based linkers and multifunctional reagents
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Probe and drug delivery system development
Storage & Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO, DCM). Avoid moisture and repeated freeze–thaw cycles.
This product provides an azide for click chemistry and a tert-butyl ester for controlled carboxyl release, linked by a PEG4 spacer specifically for solubility and efficient bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
