Azido-PEG4-Hydrazide
This product is a bifunctional PEG4 linker with a terminal azide for click chemistry and a hydrazide group for aldehyde/ketone coupling. The PEG4 spacer improves solubility and flexibility, making this reagent especially versatile for orthogonal conjugation, biomolecule labeling, and drug delivery applications.
Key Features and Benefits:
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Azide Group: Supports CuAAC or SPAAC click chemistry with alkyne partners.
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Hydrazide Group: Reacts selectively with aldehydes and ketones to form hydrazone linkages.
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PEG4 Spacer: Provides hydrophilicity, flexibility, and reduced steric hindrance.
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High Purity: Ensures reproducibility in sensitive conjugation workflows.
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Dual Reactivity: Enables orthogonal, stepwise conjugation strategies.
Applications:
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Bioconjugation: Dual-reactive linker for proteins, peptides, and glycoproteins.
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Click Chemistry: Azide–alkyne ligation for orthogonal labeling.
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Glycoconjugation: Hydrazide functionality enables modification of oxidized sugars.
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Drug Delivery: PEGylated linker enhances solubility and pharmacokinetics.
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Surface Functionalization: Functionalizes nanoparticles, hydrogels, or polymers.
Storage and Handling:
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Storage: Store at –20 °C in a dry, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve azide and hydrazide reactivity.
This product provides orthogonal click and hydrazone chemistries in a compact PEG spacer, making it an especially versatile tool for bioconjugation, glycobiology, and therapeutic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
