Azido-PEG4-CH2CO2H
Azido-PEG4-CH2CO2H is a high-purity heterobifunctional PEG linker with an azide group for bioorthogonal click chemistry (CuAAC or SPAAC) and a terminal carboxylic acid for versatile coupling to amines or other nucleophiles. The PEG4 spacer enhances aqueous solubility, improves flexibility, and reduces steric hindrance, enabling efficient bioconjugation in both aqueous and organic systems. This design is ideal for precision linker construction in drug delivery, diagnostics, and advanced biomaterials.
Key Features and Benefits
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Azide Functional Group: Enables copper-catalyzed or strain-promoted click chemistry with alkynes.
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Carboxylic Acid Group: Couples to primary amines using carbodiimide chemistry (e.g., EDC/NHS).
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PEG4 Spacer: Improves solubility, flexibility, and accessibility of reactive groups.
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Heterobifunctional Design: Supports orthogonal conjugation workflows.
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High Purity: Supplied at >95% purity for reproducible, high-yield performance.
Applications
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Stepwise Bioconjugation: Sequentially attach azide and amine-reactive partners.
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Protein and Peptide Modification: Introduce azide handles for click chemistry while retaining an acid for coupling.
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Nanoparticle and Surface Functionalization: Add bioorthogonal handles for targeted delivery systems.
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Drug Delivery Systems: Create linkers for precise payload attachment and release.
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Diagnostic Probe Development: Build multifunctional probes for imaging and biosensing.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture to preserve reactive groups.
Azido-PEG4-CH2CO2H combines azide click chemistry reactivity with a carboxylic acid handle in a hydrophilic PEG4 spacer, providing a soluble, flexible linker for multifunctional bioconjugates, precision linkers, and targeted delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
