Azido-PEG4-CH2CO2-tBu
Azido-PEG4-CH2CO2-tBu is a high-purity heterobifunctional PEG linker with an azide for click chemistry and a t-butyl ester–protected carboxylic acid for orthogonal conjugation. Its PEG4 spacer improves solubility, flexibility, and reaction efficiency, while the acid-labile t-butyl ester enables controlled deprotection for stepwise functionalization in drug delivery, diagnostics, and biomaterials.
Key Features and Benefits
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Azide Functional Group: Enables click chemistry with alkynes via copper-catalyzed or strain-promoted cycloaddition.
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t-Butyl Ester Protection: Acid-labile, allowing selective deprotection for sequential coupling.
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PEG4 Spacer: Improves solubility, flexibility, and accessibility of reactive groups.
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Heterobifunctional Design: Supports orthogonal conjugation strategies for multifunctional constructs.
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High Purity: Supplied at >95% purity for reproducibility and reliable performance.
Applications
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Stepwise Bioconjugation: Sequentially attach azide and carboxylic acid partners.
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Protein and Peptide Modification: Introduce azide handles while reserving a protected acid for later use.
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Nanoparticle and Surface Functionalization: Add bioorthogonal handles for targeted delivery.
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Drug Delivery Systems: Design linkers that enable precise payload attachment and release.
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Diagnostic Probe Development: Create multifunctional imaging and sensing probes.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture to preserve reactive groups.
Azido-PEG4-CH2CO2-tBu offers azide click chemistry reactivity with acid-protected functionality in a hydrophilic PEG4 framework, making it an especially versatile choice for multifunctional bioconjugates, precision linkers, and targeted delivery systems.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
