Azido-PEG4-alpha-D-Mannose (CAS: 1632372-86-1): Overview and Applications
Azido-PEG4-alpha-D-Mannose (CAS: 1632372-86-1) is a specialized PEG linker featuring an azide group and an alpha-D-mannose moiety. This compound is designed for bioconjugation and drug delivery applications.
Key Features:
- Azide Group: Enables copper-catalyzed click chemistry reactions with alkynes, or copper free click chemistry with DBCO, and BCN for selective conjugation.
- PEG4 Spacer: Increases solubility in aqueous media and enhances biocompatibility.
- Alpha-D-Mannose: Targets specific cells or tissues expressing mannose-binding proteins, improving the selectivity of the PEGylation reaction.
Applications:
- Bioconjugation: Links biomolecules such as proteins, peptides, and nucleic acids for targeted delivery.
- Drug Delivery: Enhances the targeting of therapeutics to specific cells, particularly in cancer and inflammation.
- Cellular Studies: Investigates mannose receptor interactions and cellular uptake mechanisms.
- Diagnostics: Supports the development of assays utilizing mannose-binding proteins.
Azido-PEG4-alpha-D-Mannose is a versatile tool for targeted therapeutics, making it essential for research in drug delivery and bioconjugation.
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