Azido-PEG3-t-butyl ester
This product is a high-purity heterobifunctional PEG linker featuring an azide group for click chemistry and a tert-butyl ester group for protected carboxyl activation, specifically connected by a short PEG3 spacer for solubility and flexibility.
Key Features and Benefits
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Azide Group – Enables bioorthogonal click chemistry (CuAAC or SPAAC) for selective conjugation.
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t-Butyl Ester Group – Protects the carboxyl functionality, allowing controlled deprotection to yield a free acid for further coupling.
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PEG3 Spacer – Provides solubility, flexibility, and reduces steric hindrance in conjugates.
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High Purity – Suitable for bioconjugation, probe development, and material science applications.
Applications
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Click chemistry for labeling and probe synthesis
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Amide bond formation after t-butyl deprotection
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Linker in drug delivery systems and diagnostics
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Surface modification and bio-orthogonal chemistry
Storage & Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Use: Dissolve in anhydrous solvents (e.g., DMF, DMSO). Avoid repeated freeze–thaw cycles.
This product provides a versatile azide handle for click chemistry and a protected ester group for carboxyl activation, with a short PEG3 spacer that specifically enhances solubility and reduces steric hindrance in bioconjugates.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
