Azido-PEG3-SS-PEG3-azide
This product is a symmetric PEG linker featuring two terminal azides connected by a cleavable disulfide bond and PEG3 spacers. The design combines bioorthogonal click reactivity with redox-sensitive cleavage, making it especially effective for controlled drug delivery, bioconjugation, and probe development.
Key Features and Benefits:
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Dual Azide Groups: Support CuAAC or SPAAC click chemistry with alkynes.
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Disulfide Bridge: Provides reversible, redox-sensitive cleavage.
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PEG3 Spacers: Add solubility, flexibility, and steric accessibility.
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Symmetric Design: Enables dual functionalization or crosslinking strategies.
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High Purity: Ensures reproducibility in advanced workflows.
Applications:
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Drug Delivery: Enables redox-triggered release in intracellular environments.
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Bioconjugation: Combines click reactivity with cleavable linkage.
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Probe Development: Builds reversible, click-ready probes for imaging or diagnostics.
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Synthetic Chemistry: Supports orthogonal, redox-sensitive conjugation strategies.
Storage and Handling:
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Storage: Store at –20 °C, sealed and protected from moisture and light.
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Handling: Use anhydrous solvents (e.g., DMSO, DMF); avoid reducing environments before use.
This product integrates dual azide groups with a disulfide bridge, offering click-ready reactivity and cleavable linkage specifically for targeted drug delivery and advanced bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
