Azido-PEG3-aminoacetic acid-NHS ester
This product is a high-purity, heterobifunctional PEG linker containing an azide group for click chemistry and an NHS ester for efficient amine coupling. The PEG3 spacer provides excellent aqueous solubility, flexibility, and reduced steric hindrance, enabling high-efficiency conjugation in both aqueous and organic systems. This reagent is ideal for dual-functional bioconjugation strategies in drug delivery, diagnostics, and surface modification.
Key Features and Benefits:
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Azide Functional Group: Supports copper-catalyzed (CuAAC) and copper-free (SPAAC) click chemistry with alkyne-containing molecules.
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NHS Ester: Rapidly couples to primary amines under mild conditions to form stable amide bonds.
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PEG3 Spacer: Improves solubility, increases linker flexibility, and minimizes nonspecific binding.
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Heterobifunctional Design: Enables orthogonal and sequential conjugation of biomolecules or surfaces.
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High Purity: Supplied at >95% purity for consistent, reproducible results.
Applications:
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Dual-Functional Bioconjugation: Combine click chemistry and amide coupling in a single molecule.
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Protein and Peptide Labeling: Introduce azide handles while modifying lysine residues or N-termini.
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Nanoparticle Functionalization: Modify surfaces for targeted delivery or imaging applications.
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Diagnostic Probe Synthesis: Build multifunctional probes for molecular imaging and biosensing.
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Drug Delivery Development: Construct PEGylated linkers for targeted and controlled drug release.
Storage and Handling:
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Storage: Store at -20°C, in a dry, dark environment.
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid exposure to moisture to preserve NHS ester activity.
Azido-PEG3-aminoacetic acid-NHS ester combines orthogonal click chemistry and amine coupling in one reagent, making it an especially versatile tool for complex bioconjugation workflows in research and therapeutic development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.