Azido-PEG24-t-butyl ester
This product has an azide for CuAAC or SPAAC click chemistry and a tert-butyl–protected carboxylic acid for mild acidic deprotection. The PEG24 spacer specifically provides excellent solubility, flexibility, and low steric hindrance for efficient, orthogonal bioconjugation in aqueous and organic systems.
Key Features and Benefits
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Azide Group – Compatible with CuAAC and SPAAC for bioorthogonal conjugation.
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t-Butyl Ester Protection – Acid-labile protection enables orthogonal functionalization strategies.
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PEG24 Spacer – Greatly enhances solubility, molecular flexibility, and accessibility of reactive groups.
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Orthogonal Reactivity – Supports sequential modifications without cross-reactivity.
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High Purity – Supplied at >95% purity for reproducible performance.
Applications
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Bioorthogonal labeling and click chemistry
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Protein, peptide, and small molecule modification
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Antibody–drug conjugate (ADC) linker design
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Multifunctional probe and nanoparticle functionalization
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture to preserve reactivity
This product combines azide click chemistry with a t-butyl–protected carboxyl, linked by a PEG24 spacer for superior solubility and flexibility, especially ideal for orthogonal conjugation in advanced bioconjugation and drug delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
