Azido-PEG24-Hydrazide
Azido-PEG24-Hydrazide is a high-purity heterobifunctional PEG linker with an azide for CuAAC or SPAAC click chemistry and a hydrazide for aldehyde/ketone conjugation. The long PEG24 spacer offers excellent hydrophilicity, flexibility, and reduced steric hindrance, making it especially ideal for linking biomolecules or surfaces requiring extended, water-soluble connectors.
Key Features
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Azide group for CuAAC or SPAAC click chemistry
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Hydrazide group for aldehyde/ketone conjugation via hydrazone formation
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Long PEG24 spacer for maximum flexibility, solubility, and minimized steric interference
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High chemical purity ensures consistent performance
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Suitable for multi-step and orthogonal bioconjugation strategies
Applications
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Dual-functional linker for orthogonal conjugation of biomolecules, peptides, proteins, or surfaces
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Construction of antibody–drug conjugates (ADCs) and targeted drug delivery systems
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Preparation of hydrophilic crosslinkers for nanoparticle or hydrogel functionalization
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Site-specific labeling in biosensors, diagnostics, and imaging probes
Storage and Handling
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Store at –20 °C, protected from light and moisture
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Bring to room temperature before opening
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Avoid repeated freeze–thaw cycles to maintain product integrity
This product is a heterobifunctional PEG linker with an azide for click chemistry and a hydrazide for aldehyde/ketone conjugation, specifically connected by a long PEG24 chain for high solubility, flexibility, and minimal steric hindrance.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
