Azido-PEG2-CH2CO2-tBu
Azido-PEG2-CH2CO2-tBu is a high-purity heterobifunctional PEG linker with an azide group for bioorthogonal click chemistry (CuAAC or SPAAC) and a t-butyl ester–protected carboxylic acid for orthogonal conjugation. The PEG2 spacer improves solubility, flexibility, and reduces steric hindrance, enabling efficient bioconjugation in both aqueous and organic systems. The acid-labile t-butyl ester allows controlled deprotection for stepwise functionalization, making it suitable for precision linker design in drug delivery, diagnostics, and advanced materials.
Key Features and Benefits
-
Azide Functional Group: Enables copper-catalyzed or strain-promoted click chemistry with alkynes.
-
t-Butyl Ester Protection: Acid-labile, allowing selective deprotection for sequential coupling.
-
PEG2 Spacer: Enhances solubility, flexibility, and accessibility of reactive groups.
-
Heterobifunctional Design: Supports orthogonal conjugation strategies.
-
High Purity: Supplied at >95% purity for reproducible, high-yield performance.
Applications
-
Stepwise Bioconjugation: Sequentially attach azide and carboxylic acid partners.
-
Protein and Peptide Modification: Introduce azide handles while reserving a protected acid for later use.
-
Nanoparticle and Surface Functionalization: Add bioorthogonal handles for targeted delivery.
-
Drug Delivery Systems: Build linkers for precise payload attachment and release.
-
Diagnostic Probe Development: Create multifunctional imaging and sensing probes.
Storage and Handling
-
Storage: Store at –20 °C, dry, and protected from light.
-
Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture to preserve reactive groups.
Azido-PEG2-CH2CO2-tBu combines azide click reactivity with an acid-protected functionality in a hydrophilic PEG2 spacer, offering a compact, soluble linker for multifunctional bioconjugates, precision linkers, and targeted delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
