Azido-PEG16-NHS Ester
This product is a long, heterobifunctional PEG linker with a terminal azide, a PEG16 spacer, and an N-hydroxysuccinimide (NHS) ester. The azide reacts in CuAAC or SPAAC click chemistry with alkynes, while the NHS ester couples efficiently with primary amines to form stable amides. The extended PEG16 chain enhances solubility, flexibility, and spatial separation, making this reagent especially useful in bioconjugation and drug delivery.
Key Features and Benefits
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Azide Group: Enables CuAAC or SPAAC click reactions with alkynes.
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NHS Ester: Couples efficiently with amines to form amide bonds.
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PEG16 Spacer: Provides excellent solubility, flexibility, and long spacing.
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Orthogonal Reactivity: Supports dual conjugation strategies.
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High Purity: Produced to ≥95% purity for reliable performance.
Applications
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Bioconjugation: Links azide- and amine-reactive biomolecules.
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Protein and Antibody Labeling: Provides dual handles for multifunctional modifications.
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Drug Delivery: Acts as a modular PEG linker in therapeutic conjugates.
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Probe Development: Builds multifunctional probes for diagnostics and imaging.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Prepare fresh solutions; NHS esters are moisture-sensitive.
This product combines long PEG spacing with dual orthogonal reactivity, specifically offering a powerful tool for advanced conjugation and therapeutic design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
