Azido-PEG12-Hydrazide
Azido-PEG12-hydrazide is a high-purity, heterobifunctional polyethylene glycol (PEG) linker with an azide group for copper-catalyzed or strain-promoted azide–alkyne cycloaddition (CuAAC or SPAAC) click chemistry, and a hydrazide group specifically for coupling with aldehydes or ketones via hydrazone formation. The PEG12 spacer provides excellent water solubility, extended linker length, and reduced steric hindrance, making it especially suitable for bioconjugation in both aqueous and organic media.
Key Features and Benefits
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Dual Functional Groups: Azide for click chemistry; hydrazide for aldehyde/ketone coupling.
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PEG12 Spacer: Long, flexible, and hydrophilic for improved solubility and reduced steric hindrance.
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High Purity: Supplied at >95% purity for consistent, reproducible results.
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Orthogonal Reactivity: Enables sequential or selective conjugations in complex workflows.
Applications
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Site-specific labeling of biomolecules, proteins, and peptides.
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Preparation of antibody–drug conjugates (ADCs) and nanoparticle functionalization.
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Conjugation of biomolecules to surfaces, carriers, or hydrogels.
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Hydrazone-based reversible linkages for drug delivery and bioconjugation studies.
Storage and Handling
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Storage: Store at –20 °C in a dry, dark environment.
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Handling: Use anhydrous solvents; protect from prolonged exposure to moisture.
A versatile PEG12 bifunctional linker combining azide click chemistry with hydrazide aldehyde/ketone coupling, especially ideal for orthogonal, multi-step bioconjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
