Azido-PEG10-amine (CAS 912849-73-1) is a bifunctional crosslinker featuring azide and amine groups connected by a decaethylene glycol (PEG₁₀) spacer. This structure enhances solubility in aqueous solutions and provides flexibility for various conjugation strategies.
Key Features:
- Molecular Formula: C₂₂H₄₆N₄O₁₀
- Molecular Weight: 526.62 g/mol
- Functional Groups: Azide (N₃) and primary amine (NH₂)
- Solubility: Highly soluble in water and common organic solvents
Applications:
- Click Chemistry:
- The azide group participates in copper-catalyzed or strain-promoted azide-alkyne cycloaddition with alkynes, DBCO, or BCN moieties, forming stable triazole linkages.
- Bioconjugation:
- The primary amine reacts with carboxylic acids or activated esters (e.g., NHS esters) to form stable amide bonds, enabling the attachment of biomolecules.
- PROTAC Synthesis:
- Serves as a linker in the development of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation.
- Antibody-Drug Conjugates (ADCs):
- Acts as a non-cleavable PEG linker in the synthesis of ADCs, enhancing solubility and pharmacokinetic properties.
Azido-PEG10-amine is a versatile reagent in chemical biology, facilitating the development of advanced therapeutics and biomolecular assemblies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
