Azido-PEG1-CH2CO2-tBu
Azido-PEG1-CH2CO2-tBu is a high-purity heterobifunctional PEG linker with an azide for click chemistry and a t-butyl ester–protected carboxylic acid for orthogonal conjugation. Its short PEG1 spacer enhances solubility and flexibility, while the acid-labile ester enables controlled deprotection for stepwise functionalization in drug delivery, diagnostics, and advanced materials.
Key Features and Benefits
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Azide Functional Group: Enables copper-catalyzed or strain-promoted click chemistry with alkynes.
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t-Butyl Ester Protection: Acid-labile, allowing selective deprotection for sequential coupling.
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PEG1 Spacer: Enhances solubility and minimizes steric hindrance while maintaining reactivity.
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Heterobifunctional Design: Supports orthogonal conjugation strategies.
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High Purity: Supplied at >95% purity for reproducible, high-yield performance.
Applications
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Stepwise Bioconjugation: Sequentially attach azide and carboxylic acid partners.
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Protein and Peptide Modification: Introduce azide handles while reserving a protected acid for later reactions.
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Nanoparticle and Surface Functionalization: Add bioorthogonal handles for targeted applications.
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Drug Delivery Systems: Build linkers for precise payload attachment and release.
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Diagnostic Probe Development: Create multifunctional probes for imaging and sensing.
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture to preserve reactive groups.
Azido-PEG1-CH2CO2-tBu combines azide click reactivity with an acid-protected functional group in a short PEG1 spacer, offering an especially compact, highly soluble linker for multifunctional bioconjugates, precision linkers, and targeted delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
