Azido-Amido-PEG8-t-butyl ester
This high-purity PEG linker has an azide for CuAAC or SPAAC click chemistry and a t-butyl–protected carboxylic acid for mild acid deprotection. The PEG8 spacer enhances solubility, flexibility, and reduces steric hindrance, enabling especially efficient orthogonal bioconjugation in aqueous and organic systems.
Key Features and Benefits
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Azide Group – Supports CuAAC or SPAAC click chemistry for rapid, selective conjugation.
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t-Butyl Ester Protection – Allows mild acid deprotection to reveal reactive carboxyl groups.
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PEG8 Spacer – Enhances solubility, flexibility, and accessibility of functional groups.
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Orthogonal Reactivity – Enables sequential modification without cross-reactivity.
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High Purity – Supplied at >95% purity for reproducibility and performance.
Applications
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Site-specific protein, peptide, and antibody modification
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Antibody–drug conjugate (ADC) linker chemistry
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Multifunctional probe and nanoparticle conjugation
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Sequential orthogonal bioconjugation workflows
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents; avoid moisture to maintain reactivity
This product combines azide click chemistry with an acid-labile t-butyl ester, linked by a PEG8 spacer for improved solubility and flexibility, making it especially ideal for orthogonal bioconjugation applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
