Azide-Poly(L-Lysine)-Thiol, MW 3.3K is a dual-functional cationic poly(amino acid) based on poly(L-lysine). It combines azide and thiol terminal groups with a compact, amine-rich PLL chain specifically for orthogonal conjugation and biomaterial research.
Key Features and Benefits
- Dual-Functional Polymer: Combines azide and thiol functionalities on a single poly(L-lysine) chain for versatile conjugation strategies.
- Cationic Poly(amino acid): Poly(L-lysine) provides positively charged primary amine groups for electrostatic interactions and functionalization.
- MW 3.3K: The low molecular weight PLL chain provides a compact cationic structure with multiple primary amine groups.
- Azide Functionality: Provides a reactive azide handle specifically for selective click chemistry with compatible alkyne-containing molecules.
- CuAAC Click Chemistry: Supports copper-catalyzed azide-alkyne cycloaddition with terminal alkynes.
- SPAAC Click Chemistry: Supports copper-free coupling with strained cyclooctynes such as DBCO and BCN.
- Thiol Functionality: Provides a sulfhydryl group specifically for coupling with compatible maleimide, OPSS, and other thiol-reactive functionalities.
- Orthogonal Functionalization: Distinct azide and thiol groups support sequential or selective conjugation under compatible reaction conditions.
- Primary Amine-Rich Structure: Lysine side chains provide multiple primary amines specifically for electrostatic interactions and additional functionalization.
Applications
- Click Chemistry: Azide functionality supports CuAAC and SPAAC reactions with compatible alkyne-containing molecules.
- Thiol Conjugation: The thiol group supports coupling with compatible maleimide, OPSS, and other thiol-reactive compounds.
- Bioconjugation: Enables attachment of compatible peptides, proteins, ligands, dyes, polymers, and other functional molecules.
- Orthogonal Conjugation: Supports research involving sequential modification through distinct azide and thiol reaction pathways.
- Polymer Functionalization: Provides multiple reactive handles for preparing functional polymer conjugates and hybrid materials.
- Nanoparticle Functionalization: Supports attachment and modification of compatible nanoparticle systems through click or thiol chemistry.
- Surface Modification: Enables functionalization of compatible surfaces through azide- or thiol-selective reactions.
- Biomaterial Research: Supports development of multifunctional polymer conjugates, surfaces, nanoparticles, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture, excessive heat, and prolonged air exposure. Minimize thiol oxidation and allow the material to reach room temperature before opening.
Azide-Poly(L-Lysine)-Thiol, MW 3.3K combines a compact, amine-rich PLL chain with azide and thiol functionalities, while its dual-reactive architecture supports click chemistry, thiol conjugation, orthogonal functionalization, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.