Auristatin F (CAS: 163768-50-1): Key Player in Targeted Cancer Therapy
Auristatin F is a potent synthetic analog of dolastatin 10, widely used in antibody-drug conjugates (ADCs) for cancer treatment. It blocks cell division by binding to tubulin and disrupting microtubules, leading to cancer cell death.
How It Works
- Microtubule Disruption: Binds to tubulin, halting microtubule assembly and stopping cell division.
- Targeted Delivery: Linked to antibodies in ADCs, Auristatin F targets cancer cells, sparing healthy tissue.
- High Potency: Not used alone; it’s delivered specifically to cancer cells via ADCs to maximize impact.
Applications
- Cancer Therapy: Effective in treating lymphomas, leukemias, and solid tumors.
- Research and Development: Used in ADC development and testing new cancer treatments.
- Overcoming Resistance: Customizable ADCs help bypass drug resistance in cancer cells.
Benefits
- Selective Targeting: Focuses on cancer cells, reducing side effects.
- High Efficacy: Strongly inhibits cancer growth at low doses.
- Versatility: Can be paired with various antibodies for different cancers.
Safety Tips
- Handle with Care: Extremely potent; use with proper safety protocols.
- Store Properly: Keep in a cool, dry place, away from light.
Why Choose Auristatin F?
Auristatin F powers advanced cancer therapies by combining high potency with targeted delivery, making it a crucial tool in modern oncology. Contact AxisPharm to learn how we can support your ADC development needs with high-quality Auristatin F.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
