Aminooxyacetamide-PEG2-azide
Aminooxyacetamide-PEG2-azide is a high-purity heterobifunctional PEG linker with an aminooxy group for chemoselective oxime ligation to aldehydes or ketones, and an azide for copper-catalyzed or strain-promoted alkyne–azide cycloaddition (CuAAC or SPAAC) click chemistry. The PEG2 spacer enhances solubility, flexibility, and reduces steric hindrance, enabling especially efficient, orthogonal bioconjugation in aqueous and organic systems.
Key Features and Benefits
-
Aminooxy Group – Reacts selectively with aldehyde or ketone groups to form stable oxime bonds.
-
Azide Group – Compatible with CuAAC and SPAAC click chemistry for bioorthogonal conjugation.
-
PEG2 Spacer – Improves solubility, flexibility, and accessibility of reactive groups.
-
Orthogonal Reactivity – Enables sequential modifications without cross-reactivity.
-
High Purity – Supplied at >95% purity for reproducible results.
Applications
-
Dual-functional linker for orthogonal conjugation
-
Protein, peptide, and glycan labeling via oxime ligation and click chemistry
-
Multifunctional probe and diagnostic agent synthesis
-
Drug delivery systems requiring site-specific conjugation
Storage and Handling
-
Storage: Store at –20 °C, dry, and protected from light
-
Handling: Use anhydrous solvents such as DMSO or DMF; avoid prolonged exposure to moisture to preserve reactivity
This product enables aldehyde/ketone oxime ligation and azide click chemistry in one linker, with a PEG2 spacer specifically for solubility and flexibility, ideal for orthogonal bioconjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
