Aminooxy-PEG8-acid
This product is a heterobifunctional linker featuring a terminal aminooxy group for oxime ligation with aldehydes/ketones and a carboxylic acid for amide coupling. The PEG8 spacer enhances solubility, flexibility, and spacing, making it especially valuable in probe development, drug delivery, and bioconjugation.
Key Features and Benefits:
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Aminooxy Group: Enables chemoselective oxime ligation with carbonyl groups.
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Carboxylic Acid: Couples efficiently with amines to form stable amide bonds.
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PEG8 Spacer: Provides solubility, hydrophilicity, and extended steric separation.
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Orthogonal Reactivity: Supports multifunctional and stepwise conjugation.
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High Purity: Ensures reproducibility in advanced workflows.
Applications:
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Bioconjugation: Couples biomolecules via carbonyl and amine handles.
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Probe Development: Builds oxime-linked probes for imaging and diagnostics.
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Drug Delivery: Provides PEGylated scaffolds with dual reactivity.
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Synthetic Chemistry: Intermediate for multifunctional linker synthesis.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid prolonged moisture exposure.
This product combines oxime ligation chemistry with amide-forming functionality in a PEG8 scaffold, specifically offering solubility and dual reactivity for advanced conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
