Aminooxy-PEG4-acid
This product is a heterobifunctional linker with an aminooxy group for oxime ligation and a terminal carboxylic acid for amide coupling. The PEG4 spacer improves solubility, flexibility, and spacing, making it especially effective for bioconjugation, drug delivery, and probe development.
Key Features and Benefits:
-
Aminooxy Group: Reacts efficiently with aldehydes and ketones to form stable oximes.
-
Carboxylic Acid: Couples with primary amines to create amide linkages.
-
PEG4 Spacer: Enhances solubility and steric accessibility.
-
High Purity: Ensures reproducibility in sensitive conjugation workflows.
-
Dual Reactivity: Enables orthogonal ligation and amide coupling.
Applications:
-
Bioconjugation: Links aldehyde- or ketone-modified biomolecules with amine-containing partners.
-
Drug Delivery: PEGylated design improves solubility and circulation stability.
-
Probe Development: Builds multifunctional probes with aldehyde-specific handles.
-
Synthetic Chemistry: Serves as a versatile intermediate in advanced conjugation strategies.
Storage and Handling:
-
Storage: Store at –20 °C in a moisture- and light-protected container.
-
Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve aminooxy reactivity.
This product combines oxime ligation with amide coupling in a compact PEG scaffold, making it an especially versatile tool for targeted conjugation and bioconjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
