Aminooxy-PEG3-Acid
This high-purity heterobifunctional PEG linker features an aminooxy group for oxime ligation with aldehydes or ketones and a terminal carboxylic acid for amide coupling with amines. The PEG3 spacer specifically enhances solubility, flexibility, and reduces steric hindrance, enabling efficient orthogonal bioconjugation in aqueous and organic systems.
Key Features and Benefits
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Aminooxy Group – Forms stable oxime bonds with aldehyde- or ketone-containing molecules under mild conditions.
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Carboxylic Acid Group – Reacts with amines for stable amide bond formation.
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PEG3 Spacer – Improves solubility and accessibility of reactive groups while minimizing steric hindrance.
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Orthogonal Reactivity – Supports sequential, site-specific modifications without cross-reactivity.
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High Purity – Supplied at >95% purity for consistent, reproducible performance.
Applications
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Protein, peptide, and glycan modification
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Antibody–drug conjugate (ADC) linker chemistry
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Hydrogel and biomaterial functionalization
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Dual-functional bioconjugation strategies
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid prolonged moisture exposure to preserve reactivity
This product combines oxime ligation via aminooxy with amide bond formation via a carboxylic acid, connected by PEG3 for solubility and flexibility, especially ideal for orthogonal bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
