Aminoethyl-SS-propionic acid
This product is a bifunctional linker featuring a terminal primary amine, a terminal carboxylic acid, and a central disulfide (–SS–) bond. It specifically enables reversible conjugation strategies, allowing controlled cleavage under reducing conditions while supporting amide coupling and further functionalization.
Key Features and Benefits
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Primary Amine: Couples with activated esters, carboxyls, or linkers.
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Carboxylic Acid: Forms stable amide bonds with amines.
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Disulfide Bond: Provides a cleavable linkage under reducing conditions.
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Dual Reactivity: Combines amine and acid functionalities with reducible chemistry.
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High Purity: Ensures reproducible results in conjugation workflows.
Applications
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Bioconjugation: Links biomolecules with controlled release via disulfide cleavage.
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Probe Development: Builds cleavable probes for diagnostics and imaging.
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Drug Delivery: Provides reducible scaffolds for therapeutic conjugates.
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Material Science: Functionalizes polymers and nanoparticles with reversible chemistry.
Storage and Handling
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Storage: Keep at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid reducing agents before intended cleavage.
This product integrates amine and acid groups with a reducible disulfide bond, specifically providing a versatile scaffold for cleavable conjugation in drug delivery, probe design, and material applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
