Amino-SS-PEG12-acid
This product is a heterobifunctional PEG linker featuring a terminal amine, a cleavable disulfide (SS) bond, and a terminal carboxylic acid. The PEG12 spacer specifically enhances solubility, flexibility, and steric spacing, making it highly effective for controlled bioconjugation, drug delivery, and probe development.
Key Features and Benefits:
-
Amine Group: Couples with activated esters and electrophiles for stable amide bonds.
-
Carboxylic Acid: Enables amide formation with primary amines.
-
Disulfide Bridge (SS): Provides cleavable, redox-sensitive linkage.
-
PEG12 Spacer: Offers extended solubility, hydrophilicity, and flexibility.
-
High Purity: Ensures reproducibility in advanced research workflows.
Applications:
-
Bioconjugation: Links biomolecules with redox-sensitive control.
-
Drug Delivery: Supports cleavable, PEGylated linkers for targeted release.
-
Probe Development: Builds reversible probes for imaging and diagnostics.
-
Material Science: Functionalizes polymers and nanoparticles with cleavable handles.
Storage and Handling:
-
Storage: Store at –20 °C in a tightly sealed, moisture- and light-protected container.
-
Handling: Use anhydrous solvents (e.g., DMF, DMSO); protect disulfide from reducing agents.
This product integrates an amine, acid, and disulfide bridge in a PEG12 chain, specifically offering controlled cleavable chemistry for versatile bioconjugation and drug delivery strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
