Amino-PEG4-Acid (NH2-PEG4-COOH), CAS number 663921-15-1, is a versatile PEG linker with an amine group (-NH2) on one end and a carboxyl group (-COOH) on the other.
Key Features:
- Structure: This PEG chain contains four ethylene glycol units. It features an amine on one end and a carboxyl on the other, allowing for easy conjugation in drug delivery and bioconjugation.
- Reactivity:
- The amine group reacts quickly with activated esters and aldehydes, forming stable bonds.
- The carboxyl group connects easily with amines and alcohols, enabling efficient linking with drugs or biomolecules.
- Applications:
- Drug Delivery: It works as a drug carrier, ADC linker, and PROTAC linker. It targets cancer cells and tumor vasculature with high efficiency while minimizing uptake in normal cells, reducing toxicity.
- Nanotechnology & Materials Science: Researchers use it in new materials development and for PEG-modified coatings, enhancing their functionality.
- Medical Research & Cell Culture: It supports drug-release studies, cell culture, and ligand or polypeptide synthesis.
- Surface Modification: It is perfect for modifying surfaces in biosensors and other biotechnological tools.
- Solubility: The PEG chain provides excellent water solubility, improving biocompatibility and reducing unwanted interactions.
Summary:
Amino-PEG4-Acid (NH2-PEG4-COOH) is a highly effective PEG linker for drug delivery and cancer therapy. It easily forms conjugates with drugs or radiotracers, targeting tumors while sparing healthy cells. It also plays a key role in nanotechnology, surface modification, and medical research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
