Alloc-Val-Ala-PAB-PNP, CAS: 1884578-27-1, is a cleavable linker for drug delivery and bioconjugation applications. It includes an allyloxycarbonyl group for temporary N-terminal protection, a Val-Ala dipeptide that enables enzyme-specific cleavage, and a para-aminobenzyl-p-nitrophenol component for controlled release of the linked molecule.
Key Features:
- Alloc Protection: Provides temporary protection for the N-terminus, removable under mild conditions.
- Enzyme-Sensitive Linker: The Val-Ala dipeptide allows specific cleavage by enzymes, ideal for drug release in targeted cells.
- Controlled Release Mechanism: The PAB-PNP component ensures a controlled release of payload after cleavage.
Applications:
- Targeted Drug Delivery: Commonly used in antibody-drug conjugates (ADCs) to enable precise, controlled release of therapeutic agents.
- Bioconjugation: Allows attachment of therapeutic molecules to proteins and peptides for targeted treatments.
- Protein and Peptide Research: Useful for temporary labeling and controlled activation in biochemical studies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
