Ald-PEG3-NHBoc
Ald-PEG3-NHBoc is a high-purity heterobifunctional PEG linker featuring an aldehyde group for oxime or hydrazone ligation with aminooxy or hydrazide functionalities, and a Boc-protected amine that can be selectively deprotected under mild acidic conditions. The PEG3 spacer specifically improves solubility, flexibility, and reduces steric hindrance in conjugation reactions.
Key Features
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Aldehyde group for oxime/hydrazone coupling
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Boc-protected amine for controlled, selective deprotection
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PEG3 spacer enhances hydrophilicity and flexibility
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High stability and purity for reliable conjugations
Applications
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Antibody–drug conjugate (ADC) synthesis
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Protein, peptide, and nanoparticle labeling
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Site-specific dual functionalization strategies
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Targeted drug delivery and diagnostic development
Storage and Handling
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Store at –20 °C, protected from moisture and light
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Warm to room temperature before use
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Avoid repeated freeze–thaw cycles
This product contains an aldehyde for oxime or hydrazone ligation and a Boc-protected amine for controlled release, specifically connected via a hydrophilic PEG3 spacer for improved solubility and reduced steric hindrance.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
