Ald-PEG3-azide, or Azido-PEG3-aldehyde (CAS: 1807530-10-4)
Ald-PEG3-azide is a heterobifunctional polyethylene glycol (PEG) linker with an aldehyde group (-CHO) at one end and an azide group (-N₃) at the other. Its dual functional groups enable versatile conjugation strategies in chemical biology and drug development.
Features:
- Molecular Formula: C₉H₁₇N₃O₄
- Molecular Weight: 231.25 g/mol
- Functional Groups:
- Aldehyde (-CHO)
- Azide (-N₃)
- PEG Spacer Length: 3 ethylene glycol units
- Purity: ≥95%
- Physical State: Colorless to off-white liquid
Applications:
- PROTAC Synthesis:
- Functions as a PEG-based linker in Proteolysis Targeting Chimeras (PROTACs), enabling targeted protein degradation.
- Click Chemistry:
- The azide group supports copper-catalyzed azide-alkyne cycloaddition (CuAAC), enabling efficient molecular conjugation.
- Bioconjugation:
- The aldehyde group forms reversible bonds with hydrazide or aminooxy groups, aiding in biomolecule conjugation such as proteins and antibodies.
- Chemical Biology Research:
- Useful for creating novel therapeutics and diagnostic tools due to its bifunctional reactivity and solubility.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
