Ald-PEG2-NHBoc
Ald-PEG2-NHBoc is a high-purity, heterobifunctional PEG linker containing an aldehyde group for oxime or hydrazone ligation and a Boc-protected amine for orthogonal conjugation. The PEG2 spacer enhances solubility, provides flexibility, and reduces steric hindrance, enabling efficient bioconjugation in both aqueous and organic systems. The protected amine allows selective deprotection for stepwise functionalization, making this reagent ideal for precision linker design in drug development, diagnostics, and material science.
Key Features and Benefits:
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Aldehyde Functional Group: Enables chemoselective conjugation with aminooxy- or hydrazide-containing molecules via oxime or hydrazone bond formation.
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Boc-Protected Amine: Allows controlled deprotection for secondary reactions and orthogonal labeling strategies.
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PEG2 Spacer: Improves aqueous solubility, flexibility, and accessibility of reactive groups.
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Heterobifunctional Design: Supports dual conjugation workflows for multifunctional bioconjugates.
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High Purity: Supplied at >95% purity for reproducibility and reliable performance.
Applications:
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Stepwise Bioconjugation: Sequentially attach biomolecules using aldehyde and amine chemistries.
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Protein and Peptide Modification: Introduce aldehyde handles while reserving an amine group for later functionalization.
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Nanoparticle and Surface Functionalization: Add bioorthogonal handles to surfaces for targeted applications.
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Drug Delivery Systems: Build linkers that enable precise payload attachment and release.
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Diagnostic Probe Development: Create multifunctional imaging and sensing probes.
Storage and Handling:
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Storage: Store at -20°C, dry, and protected from light.
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Handling: Use anhydrous solvents such as DMSO or DMF; avoid moisture to preserve aldehyde reactivity.
Ald-PEG2-NHBoc provides orthogonal reactivity with excellent solubility, making it a versatile choice for constructing multifunctional bioconjugates, precision linkers, and targeted delivery systems.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
