Ald-benzoylamide-PEG3-CH2 acid
Ald-benzoylamide-PEG3-CH2 acid is a high-purity heterobifunctional PEG linker with an aldehyde for chemoselective oxime or hydrazone ligation and a terminal carboxylic acid specifically for amide bond formation with amines. The PEG3 spacer especially improves solubility, flexibility, and reduces steric hindrance, enabling efficient, orthogonal bioconjugation in aqueous and organic systems.
Key Features and Benefits
-
Aldehyde Group – Enables oxime or hydrazone ligation with aminooxy or hydrazide groups
-
Carboxylic Acid – Forms stable amide bonds with primary amines
-
PEG3 Spacer – Enhances solubility and accessibility of reactive groups
-
Orthogonal Reactivity – Allows selective sequential conjugations
-
High Purity – >95% purity for reproducible performance
Applications
-
Protein and peptide conjugation
-
Antibody–drug conjugate (ADC) development
-
Biomolecule labeling and modification
-
Surface functionalization for biosensors
-
Dual-functional linker in synthetic biology
Storage and Handling
-
Store at –20 °C, dry, and protected from light
-
Use anhydrous solvents such as DMSO or DMF for dissolution
-
Avoid prolonged exposure to moisture to maintain reactivity
This product combines an aldehyde for oxime/hydrazone ligation with a carboxylic acid for amide coupling, separated by a PEG3 spacer for solubility and flexibility, specifically enabling efficient orthogonal bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
