Active-Mono-Sulfone-PEG8-acid contains an active sulfone and acid end group. The active sulfone group can undergo a controlled conjugation onto the two thiol groups formed by the reduction of a S-S bridge in proteins. The active-mono-sulfone linker is of great interest as it maintains the protein’s secondary and tertiary structure and has minimal effects to the protein functionalities. The terminal carboxylic acid readily reacts with primary amines in the presence of EDC, HATU and DCC, etc to from stable amide bonds. The hydrophilic PEG spacer increase the solubility of the compound in aqueous media.
Axispharm offers 3000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.