This high‑molecular‑weight carboxyl‑terminated poly(ε‑caprolactone) stands out among the PCL‑COOH product line with prolonged aliphatic chains, intensified chain entanglement and elevated crystallinity compared to 2K, 3K and 5K lower‑molecular‑weight analogues. Its terminal carboxylic acid group can be efficiently activated by EDC/NHS reagents to generate stable amide bonds with amine‑modified proteins, peptides and targeting moieties. Elongated polymer chains significantly slow hydrolytic degradation and greatly enhance mechanical robustness of nanoparticles and scaffolds. This grade fits well for month‑level in vitro assays and long‑term small‑animal studies, delivering superior colloidal stability for circulating nanocarriers, yet without the multi‑month ultra‑slow erosion behaviour of 15K and 20K ultra‑high‑MW PCL‑COOH materials.
Key Features: ‑ Long‑chain high‑crystallinity PCL backbone functionalized with terminal carboxylic‑acid group, tailored for fabricating mechanically resilient carboxyl‑functionalized particulate and scaffold systems ‑ Markedly retarded hydrolytic erosion rate, supporting weeks‑to‑month‑scale morphological retention for long‑duration in vitro and in‑vivo experimental workflows ‑ Strong intermolecular chain entanglement suppresses nanoparticle disassembly and premature payload leakage under complex biological‑media conditions ‑ Nanoparticles exhibit adjustable negative surface potential originating from terminal‑COOH groups, enabling fine‑tuning of cellular‑uptake and immune‑interaction profiles ‑ Spectroscopically confirmed carboxyl end‑group fidelity; low residual catalyst and monomer levels compatible with advanced cell assays and small‑animal pre‑clinical evaluation
Applications: ‑ Fabrication of carboxyl‑functionalized long‑persistent nanoparticles and micelles for sustained drug release and prolonged biodistribution profiling after EDC/NHS ligand conjugation ‑ EDC/NHS‑driven surface bio‑functionalization of electrospun scaffolds for mid‑long‑term tissue‑engineering investigations without strict implant‑grade durability requirements ‑ Preparation of amide‑linked polymer‑protein and polymer‑peptide conjugates for long‑acting targeted delivery in small‑animal models ‑ Development of anionic functional coating materials for biosensors requiring extended stability under biological conditions ‑ Pre‑clinical formulation validation of long‑lived particulate carriers serving as transition toward ultra‑high‑MW implant‑oriented PCL‑COOH platforms
Handling & Storage: Preserve lyophilized polymer powder at −20 °C under dry inert‑gas atmosphere. Even though carboxylic‑acid termini show good chemical stability, long‑term moisture exposure can induce random ester‑bond hydrolysis and alter molecular‑weight distribution. Keep sealed vials in a desiccator and achieve complete thermal equilibration to room temperature before opening to avoid water‑vapour‑triggered sample contamination. Prepare working solutions with anhydrous organic solvents immediately before experimental use; prolonged storage of dissolved polymer stocks is not recommended. This product is for laboratory‑research‑only and is not authorised for human clinical application.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.